Professional lifeBefore completing her graduation degree, Quijano started her career in journalism as an intern at WCIA TV in Champaign, Illinois in 1994 but was later promoted as a reporter, anchor and producer. In 1998, she axed her duty in WCIA and joined WFTS TV in Tampa, Florida as a general assignment reporter. In the beginning of 2000, she became a correspondent in CNN Newsource where she covered the 9/11 attacks and U.S. invasion of Iraq in 2003. She also covered the news on Space Shuttle Columbia disaster and the Beltway sniper attacks. In 2004, she joined CNN based in Washington D.C as a general assignment correspondent and covered the Pentagon, the Supreme Court, the re-election campaign of President George W. Bush and campaign of vice presidential candidate John Edwards.
In 2006, she became a White House correspondent for CNN. She left CNN in December 2009 and was hired by CBS News based in New York City in early 2010 as a general assignment manager. In CBS News, she covered Hurricane Sandy and Sandy Hook Elementary School massacre in 2012, the Boston Marathon bombing in 2013 and the 2014 World Cup. She is also an anchor in CBSN, the digital streaming network for CBS and the Sunday edition of CBS Weekend News. In 2009, she was the convocation speaker at the UIUC College of Media and in 2016, she was named as the moderator for the vice presidential debate by the Commission on Presidential Debates. So, she became the first Asian American to moderate a U.S. debate for national elected office in the general election and the youngest journalist to moderate a debate since 1988.